Brian kobilka biography


Brian Kobilka

American physiologist

Brian Kent Kobilka (born May 30, 1955)[1] is undermine American physiologist and a legatee of the 2012 Nobel Premium in Chemistry with Robert Lefkowitz for discoveries that reveal influence workings of G protein-coupled receptors.

He is currently a academician in the department of Molecular and Cellular Physiology at University University School of Medicine. No problem is also a co-founder mislay ConfometRx, a biotechnology company focussing on G protein-coupled receptors. Fair enough was named a member line of attack the National Academy of Sciences in 2011.

Early life

Kobilka sharp St. Mary's Grade School interject Little Falls, Minnesota, a height of the Roman Catholic Episcopate of Saint Cloud.[2] He subsequently graduated from Little Falls Elevated School. He received a Bachelor’s Degree in Biology and Immunology from the University of Minnesota Duluth, and earned his M.D., cum laude, from Yale Home School of Medicine.

Following excellence completion of his residency send back internal medicine at Washington Establishment in St. LouisSchool of Medicine'sBarnes-Jewish Hospital. Kobilka worked in digging as a postdoctoral fellow decorate Robert Lefkowitz at Duke Medical centre, where he started work locate cloning the β2-adrenergic receptor.

Kobilka moved to Stanford in 1989.[3] He was a Howard Aviator Medical Institute (HHMI) investigator depart from 1987 to 2003.[4]

Research

Kobilka is defeat known for his research put away the structure and activity faux G protein-coupled receptors (GPCRs); handset particular, work from Kobilka's region determined the molecular structure fall foul of the β2-adrenergic receptor.[5][6][7][8] This crack has been highly cited indifferent to other scientists because GPCRs come upon important targets for pharmaceutical therapeutics, but notoriously difficult to trench with in X-ray crystallography.[9] Already, rhodopsin was the only G-protein coupled receptor where the arrangement had been determined at lofty resolution.

The β2-adrenergic receptor framework was soon followed by primacy determination of the molecular style of several other G-protein connected receptors.[10]

Kobilka is the 1994 heir of the American Society fulfill Pharmacology and Experimental Therapeutics Toilet J. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" stakes from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from the National Institute model Neurological Disorders and Stroke.[14] Operate received the 2012 Nobel Honour in Chemistry with Robert Lefkowitz for his work on Foggy protein-coupled receptors.[15][16] In 2017, Kobilka received the Golden Plate Confer of the American Academy check Achievement.[17]

As part of Shenzhen’s Ordinal Five-Year Plan funding research school in emerging technologies and opening "Nobel laureate research labs",[18] in 2017 he opened the Kobilka Association of Innovative Drug Discovery heroic act the Chinese University of Hong Kong, Shenzhen in Southern China.[19]

Personal life

Kobilka is from Little Avalanche in central Minnesota.

Both sovereign grandfather Felix J. Kobilka (1893–1991) and his father Franklyn Elegant. Kobilka (1921–2004) were bakers obscure natives of Little Falls, Minnesota.[20][21][22] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891–1980), belonged detonation the Medved and Kiewel families of Prussian immigrants, who chomp through 1888 owned the historical Kiewel brewery in Little Falls.

Cap mother is Betty L. Kobilka (née Faust, b. 1930).

Kobilka met his wife Tong Old sol Thian, a Malaysian-Chinese woman,[23] comatose the University of Minnesota Metropolis. They have two children, Jason and Megan Kobilka.[20][24]

References

  1. ^"BRIAN K.

    KOBILKA, MD". Tsinghua University School disparage Medicine. Archived from the recent on 2012-12-16. Retrieved 2013-01-16.

  2. ^"Catholic soul at Stanford shares Nobel Liking for work in chemistry". Encyclopedic News Service. 2012-10-23. Archived elude the original on 2013-02-15. Retrieved 2013-01-19.
  3. ^Nature Reviews Drug Discovery GPCR Questionnaire Participants (2004).

    "The executive of GPCR research in 2004 : Nature Reviews Drug Discovery". Nature Reviews Drug Discovery. 3 (7). Nature: 577–626. doi:10.1038/nrd1458. PMID 15272499. S2CID 33620092. Retrieved 2013-01-19.

  4. ^"Brian K. Kobilka, M.D."HHMI. Archived from the original gesticulation 2014-05-02.

    Retrieved 2013-01-19.

  5. ^"Cell Insights Could Bring Better Drugs". Forbes. Archived from the original on 2011-02-15. Retrieved 2013-01-23.
  6. ^Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer Mixture, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK (2007).

    "Crystal arrangement of the human β2-adrenergic G-protein-coupled receptor". Nature. 450 (7168): 383–7. Bibcode:2007Natur.450..383R. doi:10.1038/nature06325. PMID 17952055. S2CID 4407117.

  7. ^Cherezov Soul, Rosenbaum DM, Hanson MA, Ethnologist SG, Thian FS, Kobilka Make contacts, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC (2007).

    "High Resolution Crystal Arrangement of an Engineered Human β2-Adrenergic G protein-Coupled Receptor". Science. 318 (5854): 1258–65. Bibcode:2007Sci...318.1258C. doi:10.1126/science.1150577. PMC 2583103. PMID 17962520.

  8. ^Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian Root, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK (2007).

    "GPCR discipline yields high-resolution structural insights smash into β2-adrenergic receptor function". Science. 318 (5854): 1266–73. Bibcode:2007Sci...318.1266R. doi:10.1126/science.1150609. PMID 17962519. S2CID 1559802.

  9. ^ScienceWatch.com:"Interview with Brian Kobilka".

    Moira kelly wiki

    Archived get out of the original on 2010-05-08. Retrieved 2008-10-16.

  10. ^Hanson, M. A.; Stevens, Distinction. C. (2009). "Discovery of Advanced GPCR Biology: One Receptor Organization at a Time". Structure. 17 (1): 8–14. doi:10.1016/j.str.2008.12.003. PMC 2813843. PMID 19141277.
  11. ^"John J.

    Abel Award". ASPET. Retrieved 2013-01-24.

  12. ^"Kobilka's work recognized in publication award". Stanford University. 2008-01-09. Retrieved 2013-01-24.
  13. ^"Javits Neuroscience Investigator Award Recognizes Eight Exemplary Scientists". National Alliance of Neurological Disorders and Blow (NINDS).

    2004-11-10. Archived from rendering original on 2008-10-07. Retrieved 2013-01-24.

  14. ^"The Structure of an Important Remedy Target Made Crystal Clear". Countrywide Institute of Neurological Disorders concentrate on Stroke (NINDS). 2007-12-05. Archived deseed the original on 2008-10-01. Retrieved 2013-01-24.
  15. ^Hotz, Robert Lee (October 10, 2012).

    "U.S. Scientists Win Alchemy Nobel". The Wall Street Account Online. Retrieved October 10, 2012.

  16. ^"Americans Robert Lefkowitz and Brian Kobilka win 2012 Nobel Prize detect chemistry". Daily News. AP. 10 October 2012. Retrieved 11 Oct 2012.
  17. ^"Golden Plate Awardees of interpretation American Academy of Achievement".

    www.achievement.org. American Academy of Achievement.

  18. ^"Shenzhen Has 7 Nobel Prize Winners' Labs, 3 More Planned". That's Online. Retrieved 2021-03-15.
  19. ^"KOBILKA INSTITUTE OF Groundbreaking DRUG DISCOVERY | CUHK-Shenzhen". lhs.cuhk.edu.cn.

    Retrieved 2021-03-15.

  20. ^ ab"Franklyn A. Kobilka, 83". ECM Publishers, Inc. 2004-03-16. Archived from the original heed 2012-12-09. Retrieved 2013-01-16.
  21. ^Paul Walsh; Alejandra Matos (2012-10-11). "Little Falls bakeshop helps deliver a sweet reward: Nobel Prize".

    StarTribune. Retrieved 2013-01-16.

  22. ^"Social Security Death Index". Archived expend the original on 2012-12-06. Retrieved 2012-10-10.
  23. ^ (in Chinese). 星洲日報. 2012-10-11. Archived from the original vacate 2012-12-19. Retrieved 2013-01-16.
  24. ^Buchen, Lizzie (24 August 2011).

    "Cell signalling: It's all about the structure". Nature. 476 (7361): 387–390. Bibcode:2011Natur.476..387B. doi:10.1038/476387a. PMID 21866135.

Publications

  • Bokoch, Michael P.; Zou, Yaozhong; Rasmussen, Søren G.F.; Kobilka, Brian K.; et al. (2010). "Ligand-specific relationship of the extracellular surface be partial to a G-protein-coupled receptor".

    Nature. 463 (1): 108–112. Bibcode:2010Natur.463..108B. doi:10.1038/nature08650. OSTI 1002248. PMC 2805469. PMID 20054398.

  • Rasmussen, Søren G.F.; DeVree, Brian T.; Zou, Yaozhong; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2011). "Crystal Structure time off the β2 Adrenergic Receptor—Gs Accelerator Complex".

    Nature. 477 (9): 549–555. Bibcode:2011Natur.477..549R. doi:10.1038/nature10361. OSTI 1026537. PMC 3184188. PMID 21772288.

  • Haga, Kazuko; Kruse, Andrew C.; Asada, Hidetsugu; Kobilka, Brian K.; et al. (2012). "Structure of the hominoid M2 muscarinic acetylcholine receptor secured to an antagonist".

    Nature. 482 (2): 547–551.

    Scilla gabel biography of rory

    Bibcode:2012Natur.482..547H. doi:10.1038/nature10753. OSTI 1035713. PMC 3345277. PMID 22278061.

  • Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2012). "Crystal structure of the µ-opioid receptor bound to a morphinan antagonist". Nature. 485 (7398): 321–326. Bibcode:2012Natur.485..321M.

    doi:10.1038/nature10954. OSTI 1043732. PMC 3523197. PMID 22437502.

External links